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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC6A2 All Species: 23.64
Human Site: Y590 Identified Species: 47.27
UniProt: P23975 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23975 NP_001034.1 617 69332 Y590 S L W E R L A Y G I T P E N E
Chimpanzee Pan troglodytes XP_001167680 617 69344 Y590 S L W E R L A Y G I T P E N E
Rhesus Macaque Macaca mulatta Q9MYX0 630 70239 K610 T F K E R I I K S I T P E T P
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O55192 617 69144 Y590 S L W E R V A Y G I T P E N E
Rat Rattus norvegicus P23977 619 68728 Y592 S F R E K L A Y A I T P E K D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508462 865 94609 Y838 S L R E R L A Y C L T P E N E
Chicken Gallus gallus NP_990047 635 71560 Y608 T F K E R L A Y C I T P E N E
Frog Xenopus laevis A7Y2X0 790 87434 L743 T F I E R L K L V C S P Q P D
Zebra Danio Brachydanio rerio XP_694138 678 75838 Y598 S F K E R L A Y C V T P E H E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P51905 622 69307 Q601 G G C R Q R L Q E S F Q P E D
Honey Bee Apis mellifera NP_001139210 643 71921 I577 N F I Q R L K I L T T P W R D
Nematode Worm Caenorhab. elegans Q03614 615 69247 Q586 N T I S E K W Q R V T M P Y R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 49 N.A. N.A. 94.1 66.7 N.A. 63.3 83.1 35.5 64.7 N.A. 49.2 52.2 47.4 N.A.
Protein Similarity: 100 99.6 67.1 N.A. N.A. 97.2 79.9 N.A. 67.6 88.8 53.5 75.5 N.A. 69.2 69.9 65.9 N.A.
P-Site Identity: 100 100 40 N.A. N.A. 93.3 60 N.A. 80 73.3 26.6 66.6 N.A. 0 26.6 6.6 N.A.
P-Site Similarity: 100 100 53.3 N.A. N.A. 100 73.3 N.A. 86.6 80 53.3 80 N.A. 13.3 46.6 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 59 0 9 0 0 0 0 0 0 % A
% Cys: 0 0 9 0 0 0 0 0 25 9 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 34 % D
% Glu: 0 0 0 75 9 0 0 0 9 0 0 0 67 9 50 % E
% Phe: 0 50 0 0 0 0 0 0 0 0 9 0 0 0 0 % F
% Gly: 9 9 0 0 0 0 0 0 25 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 0 25 0 0 9 9 9 0 50 0 0 0 0 0 % I
% Lys: 0 0 25 0 9 9 17 9 0 0 0 0 0 9 0 % K
% Leu: 0 34 0 0 0 67 9 9 9 9 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % M
% Asn: 17 0 0 0 0 0 0 0 0 0 0 0 0 42 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 84 17 9 9 % P
% Gln: 0 0 0 9 9 0 0 17 0 0 0 9 9 0 0 % Q
% Arg: 0 0 17 9 75 9 0 0 9 0 0 0 0 9 9 % R
% Ser: 50 0 0 9 0 0 0 0 9 9 9 0 0 0 0 % S
% Thr: 25 9 0 0 0 0 0 0 0 9 84 0 0 9 0 % T
% Val: 0 0 0 0 0 9 0 0 9 17 0 0 0 0 0 % V
% Trp: 0 0 25 0 0 0 9 0 0 0 0 0 9 0 0 % W
% Tyr: 0 0 0 0 0 0 0 59 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _